Assay Detail
Binding
CHEMBL771315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect against human protein-tyrosine phosphatase alpha (PTPalpha), using p-nitrophenyl phosphate substrate at pH 5.5.
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein phosphatase alpha (CHEMBL3918) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 4.08 | 4.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138025 | — | — | 1 | 4.28 |
| CHEMBL343979 | — | — | 1 | 4.19 |
| CHEMBL336908 | — | — | 1 | 4.05 |
| CHEMBL138659 | — | — | 1 | 4.03 |
| CHEMBL139423 | — | — | 1 | 4.00 |
| CHEMBL336435 | — | — | 1 | 4.00 |
| CHEMBL139923 | — | — | 1 | 4.00 |
| CHEMBL138806 | — | — | 1 | - |
| CHEMBL344585 | — | — | 1 | - |
| CHEMBL342612 | — | — | 1 | - |
| CHEMBL138406 | — | — | 1 | - |
| CHEMBL342478 | — | — | 1 | - |
| CHEMBL141481 | — | — | 1 | - |
| CHEMBL341806 | — | — | 1 | - |
| CHEMBL344412 | — | — | 1 | - |
| CHEMBL139422 | — | — | 1 | - |
| CHEMBL139491 | — | — | 1 | - |
| CHEMBL139024 | — | — | 1 | - |
| CHEMBL139489 | — | — | 1 | - |
| CHEMBL138713 | — | — | 1 | - |
| CHEMBL138575 | — | — | 1 | - |
| CHEMBL336894 | — | — | 1 | - |
| CHEMBL140929 | — | — | 1 | - |
| CHEMBL138257 | — | — | 1 | - |
| CHEMBL138151 | — | — | 1 | - |
| CHEMBL138152 | — | — | 1 | - |
| CHEMBL337132 | — | — | 1 | - |
| CHEMBL139356 | — | — | 1 | - |
| CHEMBL137867 | — | — | 1 | - |
| CHEMBL343587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138025 | — | Ki | = | 52000.0 | nM | 4.28 |
| CHEMBL343979 | — | Ki | = | 65000.0 | nM | 4.19 |
| CHEMBL336908 | — | Ki | = | 89000.0 | nM | 4.05 |
| CHEMBL138659 | — | Ki | = | 93000.0 | nM | 4.03 |
| CHEMBL139423 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL336435 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL139923 | — | Ki | = | 100000.0 | nM | 4.00 |
| CHEMBL342478 | — | Ki | = | 180000.0 | nM | - |
| CHEMBL341558 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL141481 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL341806 | — | Ki | = | 800000.0 | nM | - |
| CHEMBL344412 | — | Ki | = | 280000.0 | nM | - |
| CHEMBL139422 | — | Ki | = | 363000.0 | nM | - |
| CHEMBL139491 | — | Ki | = | 1789000.0 | nM | - |
| CHEMBL139024 | — | Ki | = | 530000.0 | nM | - |
| CHEMBL344585 | — | Ki | = | 980000.0 | nM | - |
| CHEMBL423546 | — | Ki | = | 210000.0 | nM | - |
| CHEMBL139590 | — | Ki | = | 250000.0 | nM | - |
| CHEMBL337759 | — | Ki | = | 210000.0 | nM | - |
| CHEMBL139050 | — | Ki | = | 870000.0 | nM | - |
| CHEMBL336879 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL337326 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL138406 | — | Ki | = | 1000000.0 | nM | - |
| CHEMBL342612 | — | Ki | = | 1700000.0 | nM | - |
| CHEMBL138806 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL139489 | — | Ki | = | 340000.0 | nM | - |
| CHEMBL138713 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL138575 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL336894 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL140929 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL138257 | — | Ki | = | 200000.0 | nM | - |
| CHEMBL138151 | — | Ki | = | 320000.0 | nM | - |
| CHEMBL138152 | — | Ki | = | 290000.0 | nM | - |
| CHEMBL337132 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL139356 | — | Ki | = | 215000.0 | nM | - |
| CHEMBL137867 | — | Ki | = | 250000.0 | nM | - |
| CHEMBL343587 | — | Ki | = | 322000.0 | nM | - |