Assay Detail
Binding
CHEMBL771319
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for the inhibitory activity against Protein-tyrosine phosphatase beta (SH-PTP1) (human PTPases.)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Receptor-type tyrosine-protein phosphatase beta (CHEMBL2706) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
PTP1B inhibition and antihyperglycemic activity in the ob/ob mouse model of novel 11-arylbenzo[b]naphtho[2,3-d]furans and 11-arylbenzo[b]naphtho[2,3-d]thiophenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.26 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL324232 | — | — | 1 | 6.30 |
| CHEMBL108721 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL324232 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL108721 | — | IC50 | = | 600.0 | nM | 6.22 |