Assay Detail
Binding
CHEMBL771467
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Compound was tested for activation of RNase L by measuring concentration required for 50% inhibition of protein synthesis in mouse L cell extracts
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | L |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activities of oligo(8-bromoadenylates) as analogues of 5'-O-triphosphoadenylyl(2'----5')adenylyl(2'----5')adenosine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.08 | 8.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL404038 | — | — | 1 | 8.64 |
| CHEMBL3143469 | — | — | 1 | 7.32 |
| CHEMBL3143411 | — | — | 1 | 6.82 |
| CHEMBL3143409 | — | — | 1 | 6.60 |
| CHEMBL3143413 | — | — | 1 | 6.00 |
| CHEMBL414948 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL404038 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL3143469 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL3143411 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL3143409 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL3143413 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL414948 | — | IC50 | = | 200000.0 | nM | - |