Assay Detail
Functional
CHEMBL771473
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Increase in intracellular cGMP concentration in atrial natriuretic factor treated rat aortic smooth muscle cells.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Cardiac atrium |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 1: 5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 5.88 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL141631 | — | — | 1 | 7.00 |
| CHEMBL141918 | — | — | 1 | 6.82 |
| CHEMBL138658 | — | — | 1 | 6.52 |
| CHEMBL140828 | — | — | 1 | 6.40 |
| CHEMBL422104 | — | — | 1 | 6.16 |
| CHEMBL344173 | — | — | 1 | 6.00 |
| CHEMBL337587 | — | — | 1 | 6.00 |
| CHEMBL140874 | — | — | 1 | 5.82 |
| CHEMBL334910 | — | — | 1 | 5.82 |
| CHEMBL344630 | — | — | 1 | 5.82 |
| CHEMBL336457 | — | — | 1 | 5.70 |
| CHEMBL138256 | — | — | 1 | 5.52 |
| CHEMBL141577 | — | — | 1 | 5.46 |
| CHEMBL141633 | — | — | 1 | 5.40 |
| CHEMBL423550 | — | — | 1 | 5.30 |
| CHEMBL337770 | — | — | 1 | 5.26 |
| CHEMBL344676 | — | — | 1 | 5.00 |
| CHEMBL139048 | — | — | 1 | - |
| CHEMBL343832 | — | — | 1 | - |
| CHEMBL502020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL141631 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL141918 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL138658 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL140828 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL422104 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL344173 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL337587 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL140874 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL334910 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL344630 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL336457 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL138256 | — | EC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL141577 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL141633 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL423550 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL337770 | — | EC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL344676 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL139048 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL343832 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL502020 | — | EC50 | > | 10000.0 | nM | - |