Assay Detail
Functional
CHEMBL771594
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Inhibition of anchorage-dependent proliferation of RAT1 v-Ha-ras-transformed cells on poly(HEMA)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oxo-piperazine derivatives of N-arylpiperazinones as inhibitors of farnesyltransferase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.76 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL348250 | — | — | 1 | 5.60 |
| CHEMBL357959 | — | — | 1 | 4.82 |
| CHEMBL125648 | — | — | 1 | 4.55 |
| CHEMBL150996 | — | — | 1 | 4.08 |
| CHEMBL151254 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL348250 | — | IC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL357959 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL125648 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL150996 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL151254 | — | IC50 | = | - | nM | - |