Assay Detail
Functional
CHEMBL771670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibitory activity against LTB4 (5-LO) formation in RBL-1 cells stimulated with the calcium ionophore A-23187
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.90 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL49249 | — | — | 1 | 6.77 |
| CHEMBL295739 | — | — | 1 | 6.42 |
| CHEMBL48814 | — | — | 1 | 6.11 |
| CHEMBL47223 | — | — | 1 | 6.08 |
| CHEMBL16434 | — | — | 1 | 6.04 |
| CHEMBL15781 | — | — | 1 | 5.92 |
| CHEMBL275835 | DARBUFELONE | 2.0 | 1 | 5.92 |
| CHEMBL15904 | — | — | 1 | 5.89 |
| CHEMBL49008 | — | — | 1 | 5.85 |
| CHEMBL8562 | — | — | 1 | 5.60 |
| CHEMBL48568 | — | — | 1 | 5.55 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL49249 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL295739 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL48814 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL47223 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL16434 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL15781 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL275835 | DARBUFELONE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL15904 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL49008 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL8562 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL48568 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 24000.0 | nM | 4.62 |