Assay Detail
Functional
CHEMBL771671
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Compound was tested for its inhibitory activity against PGF-2 alpha (CO) formation in RBL-1 cells stimulated with the calcium ionophore A-23187
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | RBL-1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.48 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295739 | — | — | 1 | 7.92 |
| CHEMBL16434 | — | — | 1 | 7.08 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 7.00 |
| CHEMBL275835 | DARBUFELONE | 2.0 | 1 | 6.96 |
| CHEMBL8562 | — | — | 1 | 6.82 |
| CHEMBL15781 | — | — | 1 | 6.47 |
| CHEMBL49008 | — | — | 1 | 6.46 |
| CHEMBL48568 | — | — | 1 | 6.19 |
| CHEMBL49249 | — | — | 1 | 6.10 |
| CHEMBL47223 | — | — | 1 | 5.77 |
| CHEMBL15904 | — | — | 1 | 5.68 |
| CHEMBL48814 | — | — | 1 | 5.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295739 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL16434 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL275835 | DARBUFELONE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL8562 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL15781 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL49008 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL48568 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL49249 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL47223 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL15904 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL48814 | — | IC50 | = | 4600.0 | nM | 5.34 |