Assay Detail
Functional
CHEMBL771940
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Compound was tested for inhibition of Pseudomonas aeruginosa 18SH in combination with Ceftriaxone (expressed in MIC).
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Pseudomonas aeruginosa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.90 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | — | 1 | 5.40 |
| CHEMBL333078 | — | — | 1 | 4.80 |
| CHEMBL124960 | — | — | 1 | 4.50 |
| CHEMBL122209 | — | — | 1 | - |
| CHEMBL123481 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6461 | Ro-481220 | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL333078 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL124960 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL122209 | — | IC50 | > | 16000.0 | nM | - |
| CHEMBL123481 | — | IC50 | > | 16000.0 | nM | - |