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Assay Detail

CHEMBL772071

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of human Prostaglandin G/H synthase 2 expressed in CHO (chinese hamster ovary) cells
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Prostaglandin G/H synthase 2 (CHEMBL230)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class.
Ouimet N, Chan CC, Charleson S, Claveau D, Gordon R, Guay D, Li CS, Ouellet M, Percival DM, Riendeau D, Wong E, Zamboni R, Prasit P.
Bioorg Med Chem Lett (1999) 9 : 151 -156
PubMed 10021918 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.83 7.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43461 1 7.89
CHEMBL287909 1 7.57
CHEMBL287919 1 7.54
CHEMBL37414 1 7.52
CHEMBL43520 1 7.37
CHEMBL289731 1 7.31
CHEMBL290739 1 6.92
CHEMBL41405 1 6.85
CHEMBL41739 1 6.66
CHEMBL289262 1 6.50
CHEMBL35992 1 6.30
CHEMBL37371 1 6.19
CHEMBL43402 1 6.06
CHEMBL434014 1 4.96
CHEMBL39013 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43461 IC50 = 13.0 nM 7.89
CHEMBL287909 IC50 = 27.0 nM 7.57
CHEMBL287919 IC50 = 29.0 nM 7.54
CHEMBL37414 IC50 = 30.0 nM 7.52
CHEMBL43520 IC50 = 43.0 nM 7.37
CHEMBL289731 IC50 = 49.0 nM 7.31
CHEMBL290739 IC50 = 120.0 nM 6.92
CHEMBL41405 IC50 = 140.0 nM 6.85
CHEMBL41739 IC50 = 220.0 nM 6.66
CHEMBL289262 IC50 = 320.0 nM 6.50
CHEMBL35992 IC50 = 500.0 nM 6.30
CHEMBL37371 IC50 = 640.0 nM 6.19
CHEMBL43402 IC50 = 870.0 nM 6.06
CHEMBL434014 IC50 = 11000.0 nM 4.96
CHEMBL39013 IC50 > 1800.0 nM -