Assay Detail
Binding
CHEMBL772120
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Inhibition of [3H]9-cis-retinoic acid binding to baculovirus expressed retinoic acid receptor RXR-beta
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 7.80 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69091 | — | — | 1 | 8.60 |
| CHEMBL75133 | IRX-4204 | 2.0 | 1 | 8.44 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.46 |
| CHEMBL308377 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69091 | — | Kd | = | 2.5 | nM | 8.60 |
| CHEMBL75133 | IRX-4204 | Kd | = | 3.6 | nM | 8.44 |
| CHEMBL705 | ALITRETINOIN | Kd | = | 35.0 | nM | 7.46 |
| CHEMBL308377 | — | Kd | = | 210.0 | nM | 6.68 |