Assay Detail
Binding
CHEMBL772124
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Effective concentration against RXR-alpha receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Conformational effects on retinoid receptor selectivity. 1. Effect of 9-double bond geometry on retinoid X receptor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.10 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.89 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.37 |
| CHEMBL86893 | — | — | 1 | 5.96 |
| CHEMBL36718 | — | — | 1 | 5.82 |
| CHEMBL86663 | — | — | 1 | 5.57 |
| CHEMBL89253 | — | — | 1 | 5.55 |
| CHEMBL87147 | — | — | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL38 | TRETINOIN | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL86893 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL36718 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL86663 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL89253 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL87147 | — | EC50 | = | 2800.0 | nM | 5.55 |