Assay Detail
Functional
CHEMBL772126
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Synergistic activation of BRL-49653 mediated PPAR gamma and retinoid X receptor alpha expressed in CV-1 cell transcriptional activation assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Expert |
Publication
Design and synthesis of fluorinated RXR modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL92050 | — | — | 1 | 8.70 |
| CHEMBL325592 | — | — | 1 | 8.57 |
| CHEMBL42314 | — | — | 1 | 8.51 |
| CHEMBL111217 | — | — | 1 | 8.19 |
| CHEMBL110195 | — | — | 1 | 8.04 |
| CHEMBL326673 | — | — | 1 | 6.84 |
| CHEMBL107555 | — | — | 1 | 6.78 |
| CHEMBL110921 | — | — | 1 | 6.60 |
| CHEMBL107554 | — | — | 1 | 6.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL92050 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL325592 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL42314 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL111217 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL110195 | — | EC50 | = | 9.2 | nM | 8.04 |
| CHEMBL326673 | — | EC50 | = | 143.4 | nM | 6.84 |
| CHEMBL107555 | — | EC50 | = | 167.4 | nM | 6.78 |
| CHEMBL110921 | — | EC50 | = | 249.1 | nM | 6.60 |
| CHEMBL107554 | — | EC50 | = | 359.4 | nM | 6.44 |