Assay Detail
Binding
CHEMBL772307
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]ATRA binding to baculovirus expressed retinoic acid receptor RAR-alpha
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 4 | 5.77 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.05 |
| CHEMBL308377 | — | — | 1 | 5.24 |
| CHEMBL69091 | — | — | 1 | 5.02 |
| CHEMBL75133 | IRX-4204 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL705 | ALITRETINOIN | Kd | = | 90.0 | nM | 7.05 |
| CHEMBL308377 | — | Kd | = | 5750.0 | nM | 5.24 |
| CHEMBL69091 | — | Kd | = | 9500.0 | nM | 5.02 |
| CHEMBL75133 | IRX-4204 | Kd | > | 30.0 | nM | - |