Assay Detail
Binding
CHEMBL772308
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Transcriptional activation for RAR alpha receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.21 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.30 |
| CHEMBL12585 | — | — | 1 | 7.96 |
| CHEMBL441231 | — | — | 1 | 7.82 |
| CHEMBL275311 | — | — | 1 | 7.68 |
| CHEMBL285179 | — | — | 1 | 7.62 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 6.99 |
| CHEMBL284167 | — | — | 1 | 6.00 |
| CHEMBL32505 | — | — | 1 | 5.34 |
| CHEMBL36464 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL12585 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL441231 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL275311 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL285179 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL284167 | — | EC50 | = | 989.0 | nM | 6.00 |
| CHEMBL32505 | — | EC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL36464 | — | EC50 | > | 1000.0 | nM | - |