Assay Detail
Binding
CHEMBL772312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Transcriptional activation for RAR beta receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.23 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL12585 | — | — | 1 | 9.40 |
| CHEMBL441231 | — | — | 1 | 9.40 |
| CHEMBL285179 | — | — | 1 | 9.30 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 8.82 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.48 |
| CHEMBL275311 | — | — | 1 | 8.40 |
| CHEMBL284167 | — | — | 1 | 7.68 |
| CHEMBL36464 | — | — | 1 | 7.68 |
| CHEMBL32505 | — | — | 1 | 7.13 |
| CHEMBL284937 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL12585 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL441231 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL285179 | — | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL38 | TRETINOIN | EC50 | = | 1.5 | nM | 8.82 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 3.3 | nM | 8.48 |
| CHEMBL275311 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL284167 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL36464 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL32505 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL284937 | — | EC50 | = | 961.0 | nM | 6.02 |