Assay Detail
Binding
CHEMBL772394
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Transcriptional activation for RAR gamma receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structural basis for the differential RXR & RAR activity of stilbene retinoid analogs
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 8.15 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285179 | — | — | 1 | 9.40 |
| CHEMBL12585 | — | — | 1 | 9.40 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 9.30 |
| CHEMBL441231 | — | — | 1 | 8.85 |
| CHEMBL275311 | — | — | 1 | 8.62 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 8.22 |
| CHEMBL36464 | — | — | 1 | 7.11 |
| CHEMBL284167 | — | — | 1 | 7.04 |
| CHEMBL32505 | — | — | 1 | 6.82 |
| CHEMBL284937 | — | — | 1 | 6.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285179 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL12585 | — | EC50 | = | 0.4 | nM | 9.40 |
| CHEMBL38 | TRETINOIN | EC50 | = | 0.5 | nM | 9.30 |
| CHEMBL441231 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL275311 | — | EC50 | = | 2.4 | nM | 8.62 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL36464 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL284167 | — | EC50 | = | 91.0 | nM | 7.04 |
| CHEMBL32505 | — | EC50 | = | 152.0 | nM | 6.82 |
| CHEMBL284937 | — | EC50 | = | 195.0 | nM | 6.71 |