Assay Detail
Binding
CHEMBL772411
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Binding affinity against RAS guanyl releasing protein using [3H]- PDBu as the labeled ligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structural basis of RasGRP binding to high-affinity PKC ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 8.44 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285801 | — | — | 1 | 9.07 |
| CHEMBL27266 | INDOLACTUM | — | 1 | 8.60 |
| CHEMBL6453 | — | — | 1 | 8.21 |
| CHEMBL7078 | — | — | 1 | 7.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285801 | — | Ki | = | 0.85 | nM | 9.07 |
| CHEMBL27266 | INDOLACTUM | Ki | = | 2.54 | nM | 8.60 |
| CHEMBL6453 | — | Ki | = | 6.15 | nM | 8.21 |
| CHEMBL7078 | — | Ki | = | 13.92 | nM | 7.86 |