Assay Detail
Binding
CHEMBL772600
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Inhibitory activity against Protein kinase A (Histone)
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 70 | 5.30 | 6.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL74637 | — | — | 1 | 6.02 |
| CHEMBL73343 | — | — | 1 | 5.98 |
| CHEMBL310260 | — | — | 1 | 5.79 |
| CHEMBL308099 | — | — | 1 | 5.63 |
| CHEMBL306856 | — | — | 1 | 5.55 |
| CHEMBL307152 | — | — | 1 | 5.53 |
| CHEMBL76464 | — | — | 1 | 5.53 |
| CHEMBL75368 | — | — | 1 | 5.52 |
| CHEMBL73781 | — | — | 1 | 5.50 |
| CHEMBL75953 | — | — | 1 | 5.48 |
| CHEMBL306501 | — | — | 1 | 5.47 |
| CHEMBL73718 | — | — | 1 | 5.43 |
| CHEMBL306367 | — | — | 1 | 5.41 |
| CHEMBL75984 | — | — | 1 | 5.39 |
| CHEMBL308979 | — | — | 1 | 5.34 |
| CHEMBL73742 | — | — | 1 | 5.28 |
| CHEMBL312292 | — | — | 1 | 5.23 |
| CHEMBL76326 | — | — | 1 | 5.21 |
| CHEMBL76337 | — | — | 1 | 5.08 |
| CHEMBL307630 | — | — | 1 | 5.04 |
| CHEMBL73764 | — | — | 1 | 5.01 |
| CHEMBL308252 | — | — | 1 | 4.94 |
| CHEMBL306082 | — | — | 1 | 4.93 |
| CHEMBL430606 | — | — | 1 | 4.89 |
| CHEMBL72069 | — | — | 1 | 4.88 |
| CHEMBL72076 | — | — | 1 | 4.85 |
| CHEMBL73794 | — | — | 1 | 4.78 |
| CHEMBL311851 | — | — | 1 | 4.75 |
| CHEMBL75610 | — | — | 1 | - |
| CHEMBL308594 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL74637 | — | IC50 | = | 949.0 | nM | 6.02 |
| CHEMBL73343 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL310260 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL308099 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL306856 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL307152 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL76464 | — | IC50 | = | 2930.0 | nM | 5.53 |
| CHEMBL75368 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL73781 | — | IC50 | = | 3150.0 | nM | 5.50 |
| CHEMBL75953 | — | IC50 | = | 3290.0 | nM | 5.48 |
| CHEMBL306501 | — | IC50 | = | 3380.0 | nM | 5.47 |
| CHEMBL73718 | — | IC50 | = | 3740.0 | nM | 5.43 |
| CHEMBL306367 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL75984 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL308979 | — | IC50 | = | 4580.0 | nM | 5.34 |
| CHEMBL73742 | — | IC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL312292 | — | IC50 | = | 5890.0 | nM | 5.23 |
| CHEMBL76326 | — | IC50 | = | 6120.0 | nM | 5.21 |
| CHEMBL76337 | — | IC50 | = | 8310.0 | nM | 5.08 |
| CHEMBL307630 | — | IC50 | = | 9140.0 | nM | 5.04 |
| CHEMBL73764 | — | IC50 | = | 9810.0 | nM | 5.01 |
| CHEMBL308252 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL306082 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL430606 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL72069 | — | IC50 | = | 13200.0 | nM | 4.88 |
| CHEMBL72076 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL73794 | — | IC50 | = | 16600.0 | nM | 4.78 |
| CHEMBL311851 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL307007 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL73413 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL74289 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL431181 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL73080 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL308542 | — | IC50 | - | nM | - | |
| CHEMBL309343 | — | IC50 | - | nM | - | |
| CHEMBL308994 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL73767 | — | IC50 | - | nM | - | |
| CHEMBL76332 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL306527 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL306045 | — | IC50 | - | nM | - | |
| CHEMBL72808 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL72754 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL76390 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL306611 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL308116 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL306034 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL72607 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL76499 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL308594 | — | IC50 | > | 2000.0 | nM | - |
| CHEMBL75610 | — | IC50 | > | 20000.0 | nM | - |