Assay Detail
Binding
CHEMBL772605
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Inhibition of protein kinase A
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
cAMP-dependent protein kinase (PKA) (CHEMBL2094138) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Preparation of synthons for the synthesis of protein kinase C inhibitors from rebeccamycin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.89 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.09 |
| CHEMBL574737 | UCN-01 | 2.0 | 2 | 7.38 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 4.59 |
| CHEMBL127277 | — | — | 1 | 4.47 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | — | 1 | 4.22 |
| CHEMBL139517 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL574737 | UCN-01 | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL574737 | UCN-01 | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL127277 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL268368 | STAUROSPORINE AGLYCON | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL139517 | — | IC50 | > | 100000.0 | nM | - |