Assay Detail
Functional
CHEMBL772609
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In vitro antagonistic activity against kinin-induced rabbit jugular vein contraction.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of new linear and cyclic bradykinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 23 | 6.47 | 7.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028838 | — | — | 1 | 7.39 |
| CHEMBL2028849 | — | — | 1 | 7.34 |
| CHEMBL2028845 | — | — | 1 | 7.20 |
| CHEMBL2028848 | — | — | 1 | 7.12 |
| CHEMBL2028837 | — | — | 1 | 7.12 |
| CHEMBL2028840 | — | — | 1 | 6.93 |
| CHEMBL2028835 | — | — | 1 | 6.84 |
| CHEMBL2028836 | — | — | 1 | 6.66 |
| CHEMBL2028841 | — | — | 1 | 6.62 |
| CHEMBL3142191 | — | — | 1 | 6.60 |
| CHEMBL2028844 | — | — | 1 | 6.51 |
| CHEMBL2028839 | — | — | 1 | 6.49 |
| CHEMBL3142190 | — | — | 1 | 6.44 |
| CHEMBL2028847 | — | — | 1 | 6.36 |
| CHEMBL3142192 | — | — | 1 | 6.33 |
| CHEMBL2028843 | — | — | 1 | 6.31 |
| CHEMBL2028846 | — | — | 1 | 6.27 |
| CHEMBL2369364 | — | — | 1 | 6.10 |
| CHEMBL2369400 | — | — | 1 | 6.07 |
| CHEMBL2369392 | — | — | 1 | 6.04 |
| CHEMBL3142173 | — | — | 1 | 5.52 |
| CHEMBL3142174 | — | — | 1 | 5.47 |
| CHEMBL2372276 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028838 | — | Kd | = | 40.74 | nM | 7.39 |
| CHEMBL2028849 | — | Kd | = | 45.71 | nM | 7.34 |
| CHEMBL2028845 | — | Kd | = | 63.1 | nM | 7.20 |
| CHEMBL2028848 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL2028837 | — | Kd | = | 75.86 | nM | 7.12 |
| CHEMBL2028840 | — | Kd | = | 117.49 | nM | 6.93 |
| CHEMBL2028835 | — | Kd | = | 144.54 | nM | 6.84 |
| CHEMBL2028836 | — | Kd | = | 218.78 | nM | 6.66 |
| CHEMBL2028841 | — | Kd | = | 239.88 | nM | 6.62 |
| CHEMBL3142191 | — | Kd | = | 251.19 | nM | 6.60 |
| CHEMBL2028844 | — | Kd | = | 309.03 | nM | 6.51 |
| CHEMBL2028839 | — | Kd | = | 323.59 | nM | 6.49 |
| CHEMBL3142190 | — | Kd | = | 363.08 | nM | 6.44 |
| CHEMBL2028847 | — | Kd | = | 436.52 | nM | 6.36 |
| CHEMBL3142192 | — | Kd | = | 467.74 | nM | 6.33 |
| CHEMBL2028843 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL2028846 | — | Kd | = | 537.03 | nM | 6.27 |
| CHEMBL2369364 | — | Kd | = | 794.33 | nM | 6.10 |
| CHEMBL2369400 | — | Kd | = | 851.14 | nM | 6.07 |
| CHEMBL2369392 | — | Kd | = | 912.01 | nM | 6.04 |
| CHEMBL3142173 | — | Kd | = | 3019.95 | nM | 5.52 |
| CHEMBL3142174 | — | Kd | = | 3388.44 | nM | 5.47 |
| CHEMBL2372276 | — | Kd | = | 7413.1 | nM | 5.13 |