Assay Detail
Binding
CHEMBL772929
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity was measured against wild-type HIV-1 protease
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 9.25 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43294 | — | — | 1 | 9.96 |
| CHEMBL433446 | — | — | 1 | 9.80 |
| CHEMBL287929 | — | — | 1 | 9.77 |
| CHEMBL418617 | — | — | 1 | 9.51 |
| CHEMBL43518 | — | — | 1 | 9.33 |
| CHEMBL290847 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43294 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL433446 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL287929 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL418617 | — | Ki | = | 0.31 | nM | 9.51 |
| CHEMBL43518 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL290847 | — | Ki | = | 80.0 | nM | 7.10 |