Assay Detail
Binding
CHEMBL772933
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Inhibitory activity against Hepatitis C NS3/NS4A protease
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Hepatitis C virus serine protease, NS3/NS4A (CHEMBL2095231) ↗| Type | PROTEIN COMPLEX |
| Organism | Hepatitis C virus |
Publication
Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.04 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263172 | — | — | 1 | 8.70 |
| CHEMBL406457 | — | — | 1 | 8.70 |
| CHEMBL409677 | — | — | 1 | 8.40 |
| CHEMBL265015 | — | — | 1 | 8.15 |
| CHEMBL421233 | — | — | 1 | 7.40 |
| CHEMBL216266 | — | — | 1 | 7.40 |
| CHEMBL214100 | — | — | 1 | 6.68 |
| CHEMBL263598 | — | — | 1 | 6.60 |
| CHEMBL116690 | — | — | 1 | 6.34 |
| CHEMBL326490 | — | — | 1 | 6.16 |
| CHEMBL263695 | — | — | 1 | 5.82 |
| CHEMBL264008 | — | — | 1 | 5.81 |
| CHEMBL265298 | — | — | 1 | 5.77 |
| CHEMBL332056 | — | — | 1 | 5.70 |
| CHEMBL116239 | — | — | 1 | 5.50 |
| CHEMBL116399 | — | — | 1 | 5.19 |
| CHEMBL116398 | — | — | 1 | 5.04 |
| CHEMBL116193 | — | — | 1 | 4.77 |
| CHEMBL116143 | — | — | 1 | 4.72 |
| CHEMBL324117 | — | — | 1 | 4.60 |
| CHEMBL115574 | — | — | 1 | 4.57 |
| CHEMBL117986 | — | — | 1 | 4.40 |
| CHEMBL325667 | — | — | 1 | 4.27 |
| CHEMBL267752 | — | — | 1 | 4.16 |
| CHEMBL2370491 | — | — | 1 | - |
| CHEMBL420317 | — | — | 1 | - |
| CHEMBL326056 | — | — | 1 | - |
| CHEMBL325232 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263172 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL406457 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL409677 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL265015 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL421233 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL216266 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL214100 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL263598 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL116690 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL326490 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL263695 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL264008 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL265298 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL332056 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL116239 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL116399 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL116398 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL116193 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL116143 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL324117 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL115574 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL117986 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL325667 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL267752 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2370491 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL420317 | — | IC50 | > | 400000.0 | nM | - |
| CHEMBL326056 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL325232 | — | IC50 | > | 200000.0 | nM | - |