Assay Detail
Binding
CHEMBL772940
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Inhibition of HIV-1 Protease activity
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 protease (CHEMBL243) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel arylsulfonamides possessing sub-picomolar HIV protease activities and potent anti-HIV activity against wild-type and drug-resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 10.05 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116 | AMPRENAVIR | 4.0 | 1 | 10.24 |
| CHEMBL5483011 | INDINAVIR | 3.0 | 1 | 10.15 |
| CHEMBL584 | NELFINAVIR | 4.0 | 1 | 9.77 |
| CHEMBL435733 | — | — | 1 | - |
| CHEMBL174779 | — | — | 1 | - |
| CHEMBL171947 | — | — | 1 | - |
| CHEMBL177470 | — | — | 1 | - |
| CHEMBL433973 | — | — | 1 | - |
| CHEMBL367454 | — | — | 1 | - |
| CHEMBL355306 | — | — | 1 | - |
| CHEMBL368496 | — | — | 1 | - |
| CHEMBL353288 | — | — | 1 | - |
| CHEMBL173569 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116 | AMPRENAVIR | Ki | = | 0.057 | nM | 10.24 |
| CHEMBL5483011 | INDINAVIR | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL584 | NELFINAVIR | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL435733 | — | Ki | = | 0.00026 | nM | - |
| CHEMBL174779 | — | Ki | = | 0.00052 | nM | - |
| CHEMBL171947 | — | Ki | = | 0.00012 | nM | - |
| CHEMBL177470 | — | Ki | = | 6.1e-05 | nM | - |
| CHEMBL433973 | — | Ki | = | 1.4e-05 | nM | - |
| CHEMBL367454 | — | Ki | = | 5.8e-05 | nM | - |
| CHEMBL355306 | — | Ki | = | 4.8e-05 | nM | - |
| CHEMBL368496 | — | Ki | = | 0.00016 | nM | - |
| CHEMBL353288 | — | Ki | = | 5.4e-05 | nM | - |
| CHEMBL173569 | — | Ki | = | 0.00021 | nM | - |