Assay Detail
Functional
CHEMBL774072
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Relaxant effect on isolated rabbit corpus cavernosum
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Tissue | Corpus cavernosum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
cGMP-specific 3',5'-cyclic phosphodiesterase (CHEMBL1827) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Novel, potent, and selective phosphodiesterase 5 inhibitors: synthesis and biological activities of a series of 4-aryl-1-isoquinolinone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 7.68 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553371 | — | — | 1 | 8.10 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 8.06 |
| CHEMBL544289 | — | — | 1 | 8.02 |
| CHEMBL553786 | — | — | 1 | 7.92 |
| CHEMBL541818 | — | — | 1 | 7.43 |
| CHEMBL538498 | — | — | 1 | 7.36 |
| CHEMBL540539 | — | — | 1 | 6.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553371 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL192 | SILDENAFIL | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL544289 | — | EC50 | = | 9.5 | nM | 8.02 |
| CHEMBL553786 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL541818 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL538498 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL540539 | — | EC50 | = | 130.0 | nM | 6.89 |