Assay Detail
Functional
CHEMBL774080
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 5-N-(ethyl isopropyl)-amiloride[EIPA]-sensitive Na+ uptake into acidified rabbit erythrocytes.
113
Total Activities
113
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Sodium/hydrogen exchanger (CHEMBL2096985) ↗| Type | PROTEIN FAMILY |
| Organism | Oryctolagus cuniculus |
Publication
(2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 113 | 7.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64889 | — | — | 1 | 8.70 |
| CHEMBL416314 | — | — | 1 | 8.32 |
| CHEMBL292311 | — | — | 1 | 8.24 |
| CHEMBL60551 | — | — | 1 | 8.23 |
| CHEMBL59697 | — | — | 1 | 8.22 |
| CHEMBL292105 | — | — | 1 | 8.17 |
| CHEMBL64360 | ENIPORIDE | 2.0 | 1 | 8.10 |
| CHEMBL303354 | — | — | 1 | 8.10 |
| CHEMBL302450 | — | — | 1 | 8.09 |
| CHEMBL302222 | — | — | 1 | 8.08 |
| CHEMBL60249 | — | — | 1 | 8.06 |
| CHEMBL62461 | — | — | 1 | 8.04 |
| CHEMBL61271 | — | — | 1 | 8.03 |
| CHEMBL294310 | — | — | 1 | 8.01 |
| CHEMBL64359 | — | — | 1 | 8.00 |
| CHEMBL64611 | — | — | 1 | 7.96 |
| CHEMBL291658 | — | — | 1 | 7.96 |
| CHEMBL64873 | — | — | 1 | 7.92 |
| CHEMBL62385 | — | — | 1 | 7.92 |
| CHEMBL304627 | — | — | 1 | 7.89 |
| CHEMBL305087 | — | — | 1 | 7.89 |
| CHEMBL418505 | — | — | 1 | 7.85 |
| CHEMBL64747 | — | — | 1 | 7.85 |
| CHEMBL294316 | — | — | 1 | 7.85 |
| CHEMBL302914 | — | — | 1 | 7.85 |
| CHEMBL64132 | — | — | 1 | 7.80 |
| CHEMBL291353 | — | — | 1 | 7.80 |
| CHEMBL293188 | — | — | 1 | 7.80 |
| CHEMBL64469 | — | — | 1 | 7.72 |
| CHEMBL59928 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64889 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL416314 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL292311 | — | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL60551 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL59697 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL292105 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL303354 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL64360 | ENIPORIDE | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL302450 | — | IC50 | = | 8.2 | nM | 8.09 |
| CHEMBL302222 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL60249 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL62461 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL61271 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL294310 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL64359 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL64611 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL291658 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL62385 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL64873 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL305087 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL304627 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL418505 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL64747 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL302914 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL294316 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL293188 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL291353 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL64132 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL64469 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL59928 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL446148 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL61983 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL61057 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL60044 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL423488 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL62299 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL64516 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL62556 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL62785 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL65714 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL59613 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL64141 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL60785 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL62025 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL436559 | CARIPORIDE | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL64564 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL65165 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL294330 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL302634 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL424229 | — | IC50 | = | 28.0 | nM | 7.55 |