Assay Detail
Functional
CHEMBL779556
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In vitro inhibition of GABA uptake in rat brain synaptic membranes
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.03 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | 1.0 | 1 | 5.52 |
| CHEMBL296263 | — | — | 1 | 4.54 |
| CHEMBL42464 | — | — | 1 | - |
| CHEMBL273481 | MUSCIMOL | 1.0 | 1 | - |
| CHEMBL40363 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96 | GAMMA-AMINOBUTYRIC ACID | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL296263 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL42464 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL273481 | MUSCIMOL | IC50 | = | 320000.0 | nM | - |
| CHEMBL40363 | — | IC50 | = | 130000.0 | nM | - |