Assay Detail
Binding
CHEMBL779557
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of [3H]-gabapentin binding to partially purified rat neocortex synaptic plasma membranes
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Enantioselective synthesis of PD144723: a potent stereospecific anticonvulsant.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.96 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1059 | PREGABALIN | 4.0 | 1 | 7.43 |
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 7.10 |
| CHEMBL88034 | — | — | 1 | 7.08 |
| CHEMBL167003 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1059 | PREGABALIN | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL940 | GABAPENTIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL88034 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL167003 | — | IC50 | = | 620.0 | nM | 6.21 |