Assay Detail
Functional
CHEMBL780518
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated for Ca++ dependent phosphodiesterase activity.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.58 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | — | 1 | 7.00 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.16 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | - |
| CHEMBL73478 | — | — | 1 | - |
| CHEMBL302511 | — | — | 1 | - |
| CHEMBL306351 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275084 | ISOBUTYLMETHYLXANTHINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL113 | CAFFEINE | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL63 | ROLIPRAM | IC50 | > | 100000.0 | nM | - |
| CHEMBL73478 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL302511 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL306351 | — | IC50 | > | 10000.0 | nM | - |