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Assay Detail

CHEMBL780519

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Evaluated for Ca++ dependent phosphodiesterase activity.
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Confidence 5 — Multiple protein complex / RNA
Curated By Expert

Target

Phosphodiesterase 1 (CHEMBL2111322)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

4-Amino[1,2,4]triazolo[4,3-a]quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapid-onset antidepressants.
Sarges R, Howard HR, Browne RG, Lebel LA, Seymour PA, Koe BK.
J Med Chem (1990) 33 : 2240 -2254
PubMed 2374150 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 19 5.63 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL310041 1 7.00
CHEMBL311616 1 6.00
CHEMBL7033 1 5.92
CHEMBL72052 1 5.70
CHEMBL72177 1 5.70
CHEMBL6958 1 5.52
CHEMBL73152 1 5.52
CHEMBL73210 1 4.70
CHEMBL442176 1 4.62
CHEMBL308834 1 -
CHEMBL428502 1 -
CHEMBL312744 1 -
CHEMBL307187 1 -
CHEMBL71106 1 -
CHEMBL308592 1 -
CHEMBL70832 1 -
CHEMBL309161 1 -
CHEMBL73039 1 -
CHEMBL72398 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL310041 IC50 = 100.0 nM 7.00
CHEMBL311616 IC50 = 1000.0 nM 6.00
CHEMBL7033 IC50 = 1200.0 nM 5.92
CHEMBL72052 IC50 = 2000.0 nM 5.70
CHEMBL72177 IC50 = 2000.0 nM 5.70
CHEMBL6958 IC50 = 3000.0 nM 5.52
CHEMBL73152 IC50 = 3000.0 nM 5.52
CHEMBL73210 IC50 = 20000.0 nM 4.70
CHEMBL442176 IC50 = 24000.0 nM 4.62
CHEMBL308834 IC50 > 100000.0 nM -
CHEMBL428502 IC50 > 10000.0 nM -
CHEMBL312744 IC50 >> 10000.0 nM -
CHEMBL307187 IC50 > 10000.0 nM -
CHEMBL71106 IC50 >> 10000.0 nM -
CHEMBL308592 IC50 >> 10000.0 nM -
CHEMBL70832 IC50 >> 10000.0 nM -
CHEMBL309161 IC50 >> 10000.0 nM -
CHEMBL73039 IC50 > 10000.0 nM -
CHEMBL72398 IC50 > 100000.0 nM -