Assay Detail
Functional
CHEMBL783629
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Ability to inhibit the conversion of [3H]-L-Arg to [3H]L-citrulline catalyzed by n-NOS from rat cerebellum
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Cerebellum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.85 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8292 | — | — | 1 | 8.22 |
| CHEMBL8365 | — | — | 1 | 7.96 |
| CHEMBL8105 | — | — | 1 | 7.75 |
| CHEMBL8281 | — | — | 1 | 7.60 |
| CHEMBL274405 | — | — | 1 | 7.40 |
| CHEMBL8041 | — | — | 1 | 7.30 |
| CHEMBL8302 | — | — | 1 | 7.10 |
| CHEMBL256147 | TILARGININE | 3.0 | 1 | 7.00 |
| CHEMBL274207 | — | — | 1 | 7.00 |
| CHEMBL8106 | — | — | 1 | 6.85 |
| CHEMBL412901 | — | — | 1 | 6.58 |
| CHEMBL268521 | — | — | 1 | 6.26 |
| CHEMBL416696 | — | — | 1 | 6.13 |
| CHEMBL8304 | — | — | 1 | 6.04 |
| CHEMBL269162 | — | — | 1 | 5.39 |
| CHEMBL8288 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8292 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL8365 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL8105 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL8281 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL274405 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL8041 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL8302 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL256147 | TILARGININE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL274207 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL8106 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL412901 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL268521 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL416696 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL8304 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL269162 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL8288 | — | IC50 | = | 10000.0 | nM | 5.00 |