Assay Detail
Functional
CHEMBL785227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against the production of thromboxane B2 (TXB2) in glycogen-induced peritoneal cells of rat
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Novel dual inhibitors of 5-lipoxygenase and thromboxane A2 synthetase: synthesis and structure-activity relationships of 3-pyridylmethyl-substituted 2-amino-6-hydroxybenzothiazole derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.29 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3216856 | — | — | 1 | 8.70 |
| CHEMBL3215555 | — | — | 1 | 7.05 |
| CHEMBL105139 | — | — | 1 | 7.05 |
| CHEMBL3217077 | — | — | 1 | 7.00 |
| CHEMBL3216618 | — | — | 1 | 6.96 |
| CHEMBL3217065 | — | — | 1 | 6.75 |
| CHEMBL104156 | — | — | 1 | 6.48 |
| CHEMBL105587 | — | — | 1 | 6.19 |
| CHEMBL3215528 | — | — | 1 | 5.89 |
| CHEMBL322015 | — | — | 1 | 5.85 |
| CHEMBL102243 | — | — | 1 | 5.70 |
| CHEMBL105386 | — | — | 1 | 5.70 |
| CHEMBL321358 | — | — | 1 | 5.40 |
| CHEMBL320394 | — | — | 1 | 5.36 |
| CHEMBL3216177 | — | — | 1 | 5.28 |
| CHEMBL420281 | — | — | 1 | 5.26 |
| CHEMBL3215733 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3216856 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3215555 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL105139 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL3217077 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3216618 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3217065 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL104156 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL105587 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL3215528 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL322015 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL102243 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL105386 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL321358 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL320394 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3216177 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL420281 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL3215733 | — | IC50 | < | 100.0 | nM | - |