Assay Detail
Functional
CHEMBL786456
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]S-(4-Nitrobenzyl)-6-thioinosine binding to adenosine uptake sites in rat brain membranes
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Equilibrative nucleoside transporter 1 (CHEMBL4604) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.27 | 6.69 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.69 |
| CHEMBL431733 | NAMODENOSON | 3.0 | 1 | 4.82 |
| CHEMBL2113557 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388757 | N6-BENZYLADENOSINE | Ki | = | 203.0 | nM | 6.69 |
| CHEMBL431733 | NAMODENOSON | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL2113557 | — | Ki | = | 49500.0 | nM | 4.30 |