Assay Detail
Binding
CHEMBL795004
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Inhibitory concentration against HSV-1 ribonucleotide reductase R1 protein binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | herpes simplex virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Ribonucleoside-diphosphate reductase large subunit (CHEMBL1830) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-function studies of peptides inhibiting the ribonucleotide reductase activity of herpes simplex virus type I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.23 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440253 | — | — | 1 | 5.82 |
| CHEMBL269718 | — | — | 1 | 5.72 |
| CHEMBL414299 | — | — | 1 | 5.55 |
| CHEMBL261962 | — | — | 1 | 5.37 |
| CHEMBL428090 | — | — | 1 | 5.25 |
| CHEMBL331824 | — | — | 1 | 5.10 |
| CHEMBL384014 | — | — | 1 | 4.92 |
| CHEMBL263439 | — | — | 1 | 4.86 |
| CHEMBL410578 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440253 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL269718 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL414299 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL261962 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL428090 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL331824 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL384014 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL263439 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL410578 | — | IC50 | = | 30000.0 | nM | 4.52 |