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Assay Detail

CHEMBL795272

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of hog kidney renin at 10e-9 M concentration
17
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Renin inhibitors. Statine-containing tetrapeptides with varied hydrophobic carboxy termini.
Bock MG, DiPardo RM, Evans BE, Rittle KE, Boger J, Poe M, LaMont BI, Lynch RJ, Ulm EH, Vlasuk GP.
J Med Chem (1987) 30 : 1853 -1857
PubMed 3309316 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.56 8.30

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL301129 1 8.30
CHEMBL297880 1 8.24
CHEMBL54886 1 8.17
CHEMBL53112 3 8.16
CHEMBL298510 2 7.96
CHEMBL412656 1 7.85
CHEMBL300498 2 7.62
CHEMBL3085574 1 7.60
CHEMBL269752 1 7.51
CHEMBL53099 2 7.20
CHEMBL54411 1 6.55
CHEMBL300442 1 6.32

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL301129 IC50 = 5.0 nM 8.30
CHEMBL297880 IC50 = 5.8 nM 8.24
CHEMBL54886 IC50 = 6.7 nM 8.17
CHEMBL53112 IC50 = 6.9 nM 8.16
CHEMBL298510 IC50 = 11.0 nM 7.96
CHEMBL412656 IC50 = 14.0 nM 7.85
CHEMBL298510 IC50 = 14.0 nM 7.85
CHEMBL53112 IC50 = 22.0 nM 7.66
CHEMBL53112 IC50 = 23.0 nM 7.64
CHEMBL300498 IC50 = 24.0 nM 7.62
CHEMBL3085574 IC50 = 25.0 nM 7.60
CHEMBL269752 IC50 = 31.0 nM 7.51
CHEMBL53099 IC50 = 63.0 nM 7.20
CHEMBL300498 IC50 = 90.0 nM 7.05
CHEMBL53099 IC50 = 170.0 nM 6.77
CHEMBL54411 IC50 = 280.0 nM 6.55
CHEMBL300442 IC50 = 480.0 nM 6.32