Assay Detail
Binding
CHEMBL795274
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of renin was measured using hog kidney renin and the radiolabeled synthetic substrate, H-Ile-His-Pro-Phe-His-Leu-[14C]Leu-Val-Tyr-Ser-OH
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Tissue | Kidney |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effects of structure on inhibition of pepsin and renin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322823 | — | — | 1 | 6.50 |
| CHEMBL112016 | — | — | 1 | - |
| CHEMBL112794 | — | — | 1 | - |
| CHEMBL113917 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322823 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL112016 | — | IC50 | > | 330000.0 | nM | - |
| CHEMBL112794 | — | IC50 | > | 330000.0 | nM | - |
| CHEMBL113917 | — | IC50 | > | 330000.0 | nM | - |