Assay Detail
Binding
CHEMBL795906
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Inhibition of rat Receptor protein-tyrosine kinase erbB2
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Receptor tyrosine-protein kinase erbB-2 (CHEMBL3848) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.15 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416031 | — | — | 1 | 9.00 |
| CHEMBL284485 | — | — | 1 | 8.00 |
| CHEMBL31407 | — | — | 1 | 8.00 |
| CHEMBL30432 | GW282974X | — | 1 | 7.75 |
| CHEMBL288557 | — | — | 1 | 7.58 |
| CHEMBL281006 | — | — | 1 | 7.57 |
| CHEMBL31653 | — | — | 1 | 7.31 |
| CHEMBL31108 | — | — | 1 | 7.31 |
| CHEMBL287591 | — | — | 1 | 7.05 |
| CHEMBL31161 | — | — | 1 | 6.54 |
| CHEMBL32464 | — | — | 1 | 6.25 |
| CHEMBL281881 | — | — | 1 | 5.36 |
| CHEMBL31615 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416031 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL284485 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL31407 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL30432 | GW282974X | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL288557 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL281006 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL31653 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL31108 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL287591 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL31161 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL32464 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL281881 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL31615 | — | IC50 | = | 6600.0 | nM | 5.18 |