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Assay Detail

CHEMBL795931

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of renin
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Canis lupus familiaris
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Renin (CHEMBL286)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency.
Bock MG, DiPardo RM, Evans BE, Freidinger RM, Rittle KE, Payne LS, Boger J, Whitter WL, LaMont BI, Ulm EH.
J Med Chem (1988) 31 : 1918 -1923
PubMed 3050088 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 7.52 9.23

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL56608 1 9.23
CHEMBL298615 1 9.00
CHEMBL299892 1 8.89
CHEMBL418305 1 8.48
CHEMBL293094 1 7.85
CHEMBL3085574 1 7.80
CHEMBL293351 1 7.70
CHEMBL291900 1 7.36
CHEMBL57352 1 7.04
CHEMBL294160 1 6.96
CHEMBL56703 1 6.92
CHEMBL3085571 1 6.54
CHEMBL57627 1 6.51
CHEMBL294393 1 6.46
CHEMBL57268 1 6.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL56608 IC50 = 0.59 nM 9.23
CHEMBL298615 IC50 = 0.99 nM 9.00
CHEMBL299892 IC50 = 1.3 nM 8.89
CHEMBL418305 IC50 = 3.3 nM 8.48
CHEMBL293094 IC50 = 14.0 nM 7.85
CHEMBL3085574 IC50 = 16.0 nM 7.80
CHEMBL293351 IC50 = 20.0 nM 7.70
CHEMBL291900 IC50 = 44.0 nM 7.36
CHEMBL57352 IC50 = 92.0 nM 7.04
CHEMBL294160 IC50 = 110.0 nM 6.96
CHEMBL56703 IC50 = 120.0 nM 6.92
CHEMBL3085571 IC50 = 290.0 nM 6.54
CHEMBL57627 IC50 = 310.0 nM 6.51
CHEMBL294393 IC50 = 350.0 nM 6.46
CHEMBL57268 IC50 = 1000.0 nM 6.00