Assay Detail
Functional
CHEMBL796050
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Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta
4
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Discovery of novel retinoic acid receptor agonists having potent antiproliferative activity in cervical cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 7.64 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL89241 | — | — | 2 | 8.66 |
| CHEMBL705 | ALITRETINOIN | 4.0 | 1 | 7.28 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL89241 | — | EC50 | = | 2.2 | nM | 8.66 |
| CHEMBL89241 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL705 | ALITRETINOIN | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL38 | TRETINOIN | EC50 | = | 105.0 | nM | 6.98 |