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Assay Detail

CHEMBL796773

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Binding
Inhibitory activity against CDP reductase.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Ribonucleoside-diphosphate reductase subunit M2 (CHEMBL1954)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu MC, Lin TS, Cory JG, Cory AH, Sartorelli AC.
J Med Chem (1996) 39 : 2586 -2593
PubMed 8691457 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.69 6.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL315999 1 6.09
CHEMBL87471 1 6.00
CHEMBL86188 1 6.00
CHEMBL314693 1 5.89
CHEMBL82809 1 5.85
CHEMBL86963 1 5.85
CHEMBL87996 1 5.77
CHEMBL420050 1 5.60
CHEMBL85661 1 5.60
CHEMBL313203 1 5.57
CHEMBL86910 1 5.05
CHEMBL85181 1 4.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL315999 IC50 = 820.0 nM 6.09
CHEMBL87471 IC50 = 1000.0 nM 6.00
CHEMBL86188 IC50 = 1000.0 nM 6.00
CHEMBL314693 IC50 = 1300.0 nM 5.89
CHEMBL82809 IC50 = 1400.0 nM 5.85
CHEMBL86963 IC50 = 1400.0 nM 5.85
CHEMBL87996 IC50 = 1700.0 nM 5.77
CHEMBL420050 IC50 = 2500.0 nM 5.60
CHEMBL85661 IC50 = 2500.0 nM 5.60
CHEMBL313203 IC50 = 2700.0 nM 5.57
CHEMBL86910 IC50 = 9000.0 nM 5.05
CHEMBL85181 IC50 = 11000.0 nM 4.96