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Assay Detail

CHEMBL796774

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory potency against Herpes Simplex virus ribonucleotide reductase
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Herpes simplex virus (type 1 / strain 17)
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Peptidomimetic inhibitors of herpes virus ribonucleotide reductase. Correlation between herpes simplex and varicella zoster virus
Llinas-Brunet M, Moss N, Scouten E, Liuzzi M, Deziel R
Bioorg Med Chem Lett (1996) 6 : 2881 -2886
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 7.35 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96993 1 9.15
CHEMBL98729 1 9.00
CHEMBL305199 1 8.52
CHEMBL95998 1 8.40
CHEMBL95766 1 8.30
CHEMBL70278 1 8.30
CHEMBL431851 1 8.12
CHEMBL305229 1 7.62
CHEMBL267068 1 6.85
CHEMBL262933 1 6.20
CHEMBL19974 1 5.40
CHEMBL1790768 1 5.10
CHEMBL430907 1 4.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96993 IC50 = 0.7 nM 9.15
CHEMBL98729 IC50 = 1.0 nM 9.00
CHEMBL305199 IC50 = 3.0 nM 8.52
CHEMBL95998 IC50 = 4.0 nM 8.40
CHEMBL95766 IC50 = 5.0 nM 8.30
CHEMBL70278 IC50 = 5.0 nM 8.30
CHEMBL431851 IC50 = 7.5 nM 8.12
CHEMBL305229 IC50 = 24.0 nM 7.62
CHEMBL267068 IC50 = 140.0 nM 6.85
CHEMBL262933 IC50 = 635.0 nM 6.20
CHEMBL19974 IC50 = 4000.0 nM 5.40
CHEMBL1790768 IC50 = 8000.0 nM 5.10
CHEMBL430907 IC50 = 25000.0 nM 4.60