Assay Detail
Binding
CHEMBL797523
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In vitro for inhibition of HIV-1 reverse transcriptase.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel non-nucleoside inhibitors of HIV-1 reverse transcriptase. 3. Dipyrido[2,3-b:2',3'-e]diazepinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.46 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL343883 | — | — | 1 | 7.16 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.08 |
| CHEMBL144820 | — | — | 1 | 7.05 |
| CHEMBL317130 | — | — | 1 | 6.89 |
| CHEMBL37343 | — | — | 1 | 6.89 |
| CHEMBL2114381 | — | — | 1 | 6.82 |
| CHEMBL2115336 | — | — | 1 | 6.72 |
| CHEMBL70850 | — | — | 1 | 6.62 |
| CHEMBL2115325 | — | — | 1 | 6.55 |
| CHEMBL2115328 | — | — | 1 | 6.54 |
| CHEMBL2115335 | — | — | 1 | 6.26 |
| CHEMBL39950 | — | — | 1 | 6.12 |
| CHEMBL2115334 | — | — | 1 | 6.12 |
| CHEMBL305041 | — | — | 1 | 6.00 |
| CHEMBL2115323 | — | — | 1 | 6.00 |
| CHEMBL2115326 | — | — | 1 | 5.89 |
| CHEMBL298243 | — | — | 1 | 5.89 |
| CHEMBL2115322 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL343883 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL144820 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL317130 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL37343 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2114381 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL2115336 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL70850 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL2115325 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL2115328 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL2115335 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL39950 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2115334 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL305041 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2115323 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2115326 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL298243 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2115322 | — | IC50 | = | 1760.0 | nM | 5.75 |