Assay Detail
Binding
CHEMBL797529
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Inhibition of wild-type HIV-1 Reverse transcriptase.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Bioisosteric modification of PETT-HIV-1 RT-inhibitors: synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.87 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88677 | — | — | 1 | 9.00 |
| CHEMBL88840 | — | — | 1 | 8.52 |
| CHEMBL91624 | — | — | 1 | 8.52 |
| CHEMBL328258 | — | — | 1 | 8.52 |
| CHEMBL91332 | — | — | 1 | 8.40 |
| CHEMBL36424 | — | — | 1 | 8.40 |
| CHEMBL88710 | — | — | 1 | 8.22 |
| CHEMBL88729 | — | — | 1 | 8.10 |
| CHEMBL88397 | — | — | 1 | 8.00 |
| CHEMBL398891 | THIOUREA, N-(5-BROMO-2-PYRIDINYL)-N'-(2-(2-CHLORO-3-ETHOXY-6-FLUOROPHENYL)ETHYL)- | 2.0 | 1 | 7.92 |
| CHEMBL254201 | — | — | 1 | 7.40 |
| CHEMBL89195 | — | — | 1 | 7.33 |
| CHEMBL88966 | — | — | 1 | 7.27 |
| CHEMBL313998 | — | — | 1 | 7.10 |
| CHEMBL539427 | — | — | 1 | 6.75 |
| CHEMBL91942 | — | — | 1 | 6.40 |
| CHEMBL414887 | — | — | 1 | - |
| CHEMBL90204 | — | — | 1 | - |
| CHEMBL89082 | — | — | 1 | - |
| CHEMBL327777 | — | — | 1 | - |
| CHEMBL91473 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88677 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL88840 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL91624 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL328258 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL91332 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL36424 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL88710 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL88729 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL88397 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL398891 | THIOUREA, N-(5-BROMO-2-PYRIDINYL)-N'-(2-(2-CHLORO-3-ETHOXY-6-FLUOROPHENYL)ETHYL)- | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL254201 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL89195 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL88966 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL313998 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL539427 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL91942 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL414887 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL90204 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL89082 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL327777 | — | IC50 | < | 27.0 | nM | - |
| CHEMBL91473 | — | IC50 | < | 25.0 | nM | - |