Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL797532

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro HIV-1 RT inhibitory activity using rC.dG as template-primer
ChEMBL ↗
72
Total Activities
72
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Human immunodeficiency virus 1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗
Type SINGLE PROTEIN
Organism Human immunodeficiency virus 1

Publication

Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 2. Analogues of 3-aminopyridin-2(1H)-one.
Saari WS, Wai JS, Fisher TE, Thomas CM, Hoffman JM, Rooney CS, Smith AM, Jones JH, Bamberger DL, Goldman ME.
J Med Chem (1992) 35 : 3792 -3802
PubMed 1279173 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 72 6.19 7.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL268871 L-697661 — 1 7.72
CHEMBL37803 — — 1 7.70
CHEMBL339203 — — 1 7.64
CHEMBL83825 — — 1 7.52
CHEMBL125336 — — 1 7.38
CHEMBL338263 — — 1 7.37
CHEMBL99992 — — 1 7.26
CHEMBL123636 — — 1 7.24
CHEMBL125232 — — 1 7.24
CHEMBL339090 — — 1 7.19
CHEMBL436200 — — 1 7.16
CHEMBL125299 — — 1 7.04
CHEMBL124430 — — 1 6.99
CHEMBL122293 — — 1 6.98
CHEMBL124786 — — 1 6.96
CHEMBL420519 — — 1 6.95
CHEMBL126634 — — 1 6.94
CHEMBL99018 — — 1 6.92
CHEMBL124526 — — 1 6.82
CHEMBL127564 — — 1 6.75
CHEMBL124594 — — 1 6.72
CHEMBL415320 — — 1 6.68
CHEMBL124726 — — 1 6.58
CHEMBL338992 — — 1 6.55
CHEMBL124557 — — 1 6.52
CHEMBL124149 — — 1 6.52
CHEMBL316785 — — 1 6.48
CHEMBL123553 — — 1 6.47
CHEMBL125510 — — 1 6.47
CHEMBL431274 — — 1 6.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL268871 L-697661 IC50 = 19.0 nM 7.72
CHEMBL37803 — IC50 = 20.0 nM 7.70
CHEMBL339203 — IC50 = 23.0 nM 7.64
CHEMBL83825 — IC50 = 30.0 nM 7.52
CHEMBL125336 — IC50 = 42.0 nM 7.38
CHEMBL338263 — IC50 = 43.0 nM 7.37
CHEMBL99992 — IC50 = 55.0 nM 7.26
CHEMBL123636 — IC50 = 57.0 nM 7.24
CHEMBL125232 — IC50 = 58.0 nM 7.24
CHEMBL339090 — IC50 = 65.0 nM 7.19
CHEMBL436200 — IC50 = 70.0 nM 7.16
CHEMBL125299 — IC50 = 92.0 nM 7.04
CHEMBL124430 — IC50 = 103.0 nM 6.99
CHEMBL122293 — IC50 = 105.0 nM 6.98
CHEMBL124786 — IC50 = 110.0 nM 6.96
CHEMBL420519 — IC50 = 113.0 nM 6.95
CHEMBL126634 — IC50 = 115.0 nM 6.94
CHEMBL99018 — IC50 = 120.0 nM 6.92
CHEMBL124526 — IC50 = 150.0 nM 6.82
CHEMBL127564 — IC50 = 180.0 nM 6.75
CHEMBL124594 — IC50 = 190.0 nM 6.72
CHEMBL415320 — IC50 = 210.0 nM 6.68
CHEMBL124726 — IC50 = 260.0 nM 6.58
CHEMBL338992 — IC50 = 280.0 nM 6.55
CHEMBL124149 — IC50 = 300.0 nM 6.52
CHEMBL124557 — IC50 = 300.0 nM 6.52
CHEMBL316785 — IC50 = 330.0 nM 6.48
CHEMBL123553 — IC50 = 335.0 nM 6.47
CHEMBL125510 — IC50 = 335.0 nM 6.47
CHEMBL431274 — IC50 = 350.0 nM 6.46
CHEMBL124453 — IC50 = 430.0 nM 6.37
CHEMBL123778 — IC50 = 440.0 nM 6.36
CHEMBL318730 — IC50 = 460.0 nM 6.34
CHEMBL125397 — IC50 = 470.0 nM 6.33
CHEMBL121835 — IC50 = 500.0 nM 6.30
CHEMBL123639 — IC50 = 530.0 nM 6.28
CHEMBL415716 — IC50 = 600.0 nM 6.22
CHEMBL126214 — IC50 = 654.0 nM 6.18
CHEMBL338872 — IC50 = 970.0 nM 6.01
CHEMBL124556 — IC50 = 1050.0 nM 5.98
CHEMBL124992 — IC50 = 1050.0 nM 5.98
CHEMBL121834 — IC50 = 1100.0 nM 5.96
CHEMBL124991 — IC50 = 1130.0 nM 5.95
CHEMBL125666 — IC50 = 1150.0 nM 5.94
CHEMBL338658 — IC50 = 1250.0 nM 5.90
CHEMBL124186 — IC50 = 1250.0 nM 5.90
CHEMBL125504 — IC50 = 1650.0 nM 5.78
CHEMBL123966 — IC50 = 1750.0 nM 5.76
CHEMBL124838 — IC50 = 1900.0 nM 5.72
CHEMBL125120 — IC50 = 1950.0 nM 5.71