Assay Detail
Binding
CHEMBL797540
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rhodesain from Trypanosoma brucei rhodesiense
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.96 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88734 | — | — | 1 | 7.30 |
| CHEMBL323975 | — | — | 1 | 7.05 |
| CHEMBL108101 | — | — | 1 | 6.48 |
| CHEMBL108865 | — | — | 1 | 6.26 |
| CHEMBL111632 | — | — | 1 | 6.10 |
| CHEMBL108035 | — | — | 1 | 5.96 |
| CHEMBL109619 | — | — | 1 | 5.75 |
| CHEMBL326220 | — | — | 1 | 5.40 |
| CHEMBL108700 | — | — | 1 | 5.40 |
| CHEMBL109893 | — | — | 1 | 5.10 |
| CHEMBL107612 | — | — | 1 | 4.75 |
| CHEMBL73007 | — | — | 1 | - |
| CHEMBL108077 | — | — | 1 | - |
| CHEMBL416771 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88734 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL323975 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL108101 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL108865 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL111632 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL108035 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL109619 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL326220 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL108700 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL109893 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL107612 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL73007 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL108077 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL416771 | — | IC50 | > | 20000.0 | nM | - |