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Assay Detail

CHEMBL798308

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Transcriptional activation in CV-1 cells expressing retinoid X receptor RXR alpha
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Cell Type CV-1
Confidence 9 — Direct single protein target
Curated By Expert

Target

Retinoic acid receptor RXR-alpha (CHEMBL3084)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias.
Muccio DD, Brouillette WJ, Breitman TR, Taimi M, Emanuel PD, Zhang X, Chen G, Sani BP, Venepally P, Reddy L, Alam M, Simpson-Herren L, Hill DL.
J Med Chem (1998) 41 : 1679 -1687
PubMed 9572893 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 1 6.66 6.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL43833 1 6.66

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL43833 EC50 = 220.0 nM 6.66