Assay Detail

CHEMBL798318

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Functional

Agonistic activity towards retinoid X receptor-beta

ChEMBL ↗

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Target

Retinoic acid receptor RXR-beta (CHEMBL1870) ↗

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Retinoic acid receptor RXR-beta (CHEMBL1870) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Retinoic acid receptor RXR-beta

CHEMBL1870

Anchored from Assay target.

Protein identity Retinoic acid receptor RXR-beta

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Retinoic acid receptor RXR-beta (CHEMBL1870) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Regulation of retinoidal actions by diazepinylbenzoic acids. Retinoid synergists which activate the RXR-RAR heterodimers.

Umemiya H, Fukasawa H, Ebisawa M, Eyrolles L, Kawachi E, Eisenmann G, Gronemeyer H, Hashimoto Y, Shudo K, Kagechika H.
J Med Chem (1997) 40 : 4222 -4234
PubMed 9435893 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	2	7.85	8.42

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL705	ALITRETINOIN	4.0	1	8.42
CHEMBL38	TRETINOIN	4.0	1	7.27

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL705	ALITRETINOIN	Ki	=	3.8	nM	8.42
CHEMBL38	TRETINOIN	Ki	=	54.0	nM	7.27