Assay Detail
Binding
CHEMBL798323
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Inhibitory activity against Y181C mutant HIV-1 reverse transcriptase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
(-)-6-Chloro-2-[(1-furo[2, 3-c]pyridin-5-ylethyl)thio]-4-pyrimidinamine, PNU-142721, a new broad spectrum HIV-1 non-nucleoside reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.09 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL280541 | — | — | 1 | 6.75 |
| CHEMBL280752 | — | — | 1 | 6.44 |
| CHEMBL593 | DELAVIRDINE | 4.0 | 1 | 5.08 |
| CHEMBL26752 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL280541 | — | IC50 | = | 179.0 | nM | 6.75 |
| CHEMBL280752 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL593 | DELAVIRDINE | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL26752 | — | IC50 | > | 50000.0 | nM | - |