Assay Detail
Binding
CHEMBL798331
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Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and anti-HIV activities of urea-PETT analogs belonging to a new class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.42 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL37024 | — | — | 1 | 7.82 |
| CHEMBL37835 | — | — | 1 | 7.70 |
| CHEMBL37025 | — | — | 1 | 7.30 |
| CHEMBL38318 | — | — | 1 | 7.16 |
| CHEMBL37834 | — | — | 1 | 7.05 |
| CHEMBL37762 | — | — | 1 | 6.92 |
| CHEMBL287317 | — | — | 1 | 6.85 |
| CHEMBL36424 | — | — | 1 | 6.62 |
| CHEMBL38341 | — | — | 1 | 6.57 |
| CHEMBL35729 | — | — | 1 | 6.30 |
| CHEMBL39665 | — | — | 1 | 5.82 |
| CHEMBL39999 | TROVIRDINE | 2.0 | 1 | 5.50 |
| CHEMBL40562 | — | — | 1 | 5.00 |
| CHEMBL35434 | — | — | 1 | 4.92 |
| CHEMBL268871 | L-697661 | — | 1 | 4.82 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL37024 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL37835 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL37025 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL38318 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL37834 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL37762 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL287317 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL36424 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL38341 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL35729 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL39665 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL39999 | TROVIRDINE | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL40562 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL35434 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL268871 | L-697661 | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 160000.0 | nM | - |