Assay Detail
Binding
CHEMBL798353
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Compound was evaluated for inhibition of WT HIV type I reverse transcriptase.
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 6.35 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL444080 | — | — | 1 | 7.30 |
| CHEMBL145049 | — | — | 1 | 7.22 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 7.10 |
| CHEMBL445136 | — | — | 1 | 7.10 |
| CHEMBL359195 | — | — | 1 | 7.00 |
| CHEMBL144061 | — | — | 1 | 6.96 |
| CHEMBL145273 | — | — | 1 | 6.96 |
| CHEMBL144642 | — | — | 1 | 6.92 |
| CHEMBL358292 | — | — | 1 | 6.85 |
| CHEMBL147800 | — | — | 1 | 6.72 |
| CHEMBL358143 | — | — | 1 | 6.70 |
| CHEMBL145796 | — | — | 1 | 6.62 |
| CHEMBL341667 | — | — | 1 | 6.57 |
| CHEMBL144872 | — | — | 1 | 6.54 |
| CHEMBL342342 | — | — | 1 | 6.48 |
| CHEMBL357250 | — | — | 1 | 6.47 |
| CHEMBL146828 | — | — | 1 | 6.39 |
| CHEMBL143250 | — | — | 1 | 6.38 |
| CHEMBL434122 | — | — | 1 | 6.38 |
| CHEMBL145158 | — | — | 1 | 6.34 |
| CHEMBL145893 | — | — | 1 | 6.31 |
| CHEMBL356313 | — | — | 1 | 6.24 |
| CHEMBL144591 | — | — | 1 | 6.19 |
| CHEMBL356278 | — | — | 1 | 6.16 |
| CHEMBL145279 | — | — | 1 | 6.10 |
| CHEMBL142478 | — | — | 1 | 6.07 |
| CHEMBL357664 | — | — | 1 | 6.04 |
| CHEMBL422839 | — | — | 1 | 5.99 |
| CHEMBL145730 | — | — | 1 | 5.99 |
| CHEMBL357877 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL444080 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL145049 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL445136 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL359195 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL144061 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL145273 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL144642 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL358292 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL147800 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL358143 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL145796 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL341667 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL144872 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL342342 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL357250 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL146828 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL143250 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL434122 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL145158 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL145893 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL356313 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL144591 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL356278 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL145279 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL142478 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL357664 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL422839 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL145730 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL357877 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL141443 | — | IC50 | = | 1130.0 | nM | 5.95 |
| CHEMBL433925 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL358782 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL145272 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL342794 | — | IC50 | = | 2430.0 | nM | 5.61 |
| CHEMBL39343 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL144476 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL344562 | — | IC50 | = | 4000.0 | nM | 5.40 |