Assay Detail
Binding
CHEMBL798354
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Compound was evaluated for inhibition of Y181C HIV type I reverse transcriptase.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Human immunodeficiency virus type 1 reverse transcriptase (CHEMBL247) ↗| Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
Publication
Novel non-nucleoside inhibitors of human immunodeficiency virus type 1 reverse transcriptase. 5. 4-Substituted and 2,4-disubstituted analogs of nevirapine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.95 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL342342 | — | — | 1 | 6.38 |
| CHEMBL445136 | — | — | 1 | 6.37 |
| CHEMBL359195 | — | — | 1 | 6.00 |
| CHEMBL145273 | — | — | 1 | 5.97 |
| CHEMBL147800 | — | — | 1 | 5.95 |
| CHEMBL357250 | — | — | 1 | 5.89 |
| CHEMBL145049 | — | — | 1 | 5.86 |
| CHEMBL144642 | — | — | 1 | 5.59 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL342342 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL445136 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL359195 | — | IC50 | = | 1010.0 | nM | 6.00 |
| CHEMBL145273 | — | IC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL147800 | — | IC50 | = | 1120.0 | nM | 5.95 |
| CHEMBL357250 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL145049 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL144642 | — | IC50 | = | 2580.0 | nM | 5.59 |
| CHEMBL57 | NEVIRAPINE | IC50 | = | 2600.0 | nM | 5.58 |